Welcome!
Talos Lab is a member of Stony Brook Cancer Center, under both the Department of Urology and Department of Pathology at Stony Brook Medicine.
Our main research focus is urological cancer, with an emphasis on mechanisms of intratumor heterogeneity and clonal diversification in prostate and bladder cancer. Our research makes use of in vivo analyses of genetically engineered mouse models, organoid culture systems, and multi-omics systems biology approaches. Current projects are focused on clonal dynamics in normal prostate homeostasis and aging, identification of novel biomarkers/mechanisms of drug resistance, and immunomodulatory interventions on the tumor landscape. In addition, we pursue tissue engineering approaches for developing new cancer model systems and regenerative medicine applications.